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15 . 1 Types of Mutation ExampleresultNO MUTATION ABC POINT MUTATION Base substitution Substitution of one or a few bases
1 Types of Mutation ExampleresultNO MUTATION ABC POINT MUTATION Base substitution Substitution of one or a few bases
Types of Mutation ExampleresultNO MUTATION ABC POINT MUTATION Base substitution Substitution of one or a few bases
a single amino acid substitutionwould resultfrom a point mutation ( single base substitution within a codon
DNA polymerase mutationresultsfrom a base change point mutation
neighboring base pairsinfluenced2AP - induced base substitution mutation rates
single - base mutationscausingamino acid substitutions , frameshift mutations
Point Mutations result in the substitution of a base Point Mutationsresultin the substitution of a base Frameshift Mutations
Only one of themcan resultin delayed base substitution mutations
anti-[BP]-N(2)-dG adductcan causeall three base substitution mutations
frame shift mutation(passive) were caused Base pair substitution mutation and
The presence of etheno basesmainly leadto base pair substitution mutations
were shownto causetargeted base substitution mutations
Their incorporation into the DNAmay leadto base substitution mutations
A frameshift mutation iswill discoverindels Frameshift Mutation
agentscausebase substitution mutations
replicationwould causebase substitution mutations
the major adductdid ... causebase substitution mutations
a novel deleterious homozygous four - nucleotide deletioncausingframeshift mutation
It is predictedto causean amino acid substitution ( missense mutation
Some analogs may be incorporated into nucleic acids in place of the normal baseoften resultingin a base substitution mutation
Single nucleotide polymorphism ( SNPresultsfrom a base substitution mutation
deletionledto frameshift mutation Frameshift mutation
by the substitution of a one or more DNA bases in a strand(passive) caused byPoint mutation Mutation
Point Mutationsresultin the substitution of a base Point Mutations
by PCR(passive) caused bythe base mutation
the substitution of one nucleotide with another ( such as the substitution of a T for a C).(passive) are caused by Substitution mutations
errorsresultfrom substitution mutations
Chemical mutagensusually causesubstitution mutations
by chemicals or malfunction of DNA replication(passive) often caused bySubstitution mutations
by Cas9(passive) caused bysubstitution mutations
Abou Jamra R.leadsMAN1B1 mutation
substitution mutationsresultsin substitution mutation
by the conversion of a base to the other base of the same class(passive) caused bybase substitution
the possible changescan resultfrom a substitution mutation
A silent mutationcausesbase substitution
a potentialto causebase - substitution
a number of sources directly related to the reading and storage of DNA(passive) can be caused byA substitution mutation
a base analogcan causea substitution mutation
or thymineresultingin a substitution mutation
the replacement of a single base nucleotide with another nucleotidecausesthe replacement of a single base nucleotide with another nucleotide
in the formation of a different proteinmight resultin the formation of a different protein
in a premature stop codon or a different amino acid in a protein productMay resultin a premature stop codon or a different amino acid in a protein product
to the specification of a different amino acid that in turn altersleadsto the specification of a different amino acid that in turn alters
a change in the function of a proteincausesa change in the function of a protein
in a change in the sequence of amino acids in a protein 21 Mutationsdoes ... resultin a change in the sequence of amino acids in a protein 21 Mutations
in a STOP codonresultsin a STOP codon
to an early stop codon mutationleadingto an early stop codon mutation
a missense mutation in one of the polypeptide chains of hemoglobincausesa missense mutation in one of the polypeptide chains of hemoglobin
an amino acid replacementcausesan amino acid replacement
an amino acid to be inserted at that codon that differs from that in the wild typecausesan amino acid to be inserted at that codon that differs from that in the wild type
a truncated protein structurecan causea truncated protein structure
a single replacement of an amino acid in a protein to anothercausesa single replacement of an amino acid in a protein to another
in the formation ofcan resultin the formation of
cell and tissue dysfunction with agecausecell and tissue dysfunction with age
The blood disease Sickle - cell anemia(passive) is caused byThe blood disease Sickle - cell anemia
in the amino acid substitutionresultsin the amino acid substitution
Sickle cell anemia(passive) is caused bySickle cell anemia
the replacement of a single base nucleotide with another nucleotide in DNAcausesthe replacement of a single base nucleotide with another nucleotide in DNA
that codes for one of these proteinscan leadthat codes for one of these proteins
the replacement of single base nucleotide with another nucleotidecausesthe replacement of single base nucleotide with another nucleotide
in a mutation from an amino acid residue to a stop codon ( a protein truncationresultin a mutation from an amino acid residue to a stop codon ( a protein truncation
prematurecausingpremature
in the alteration of a single amino acidresultsin the alteration of a single amino acid
changes at the translational level for the amino acid being encodedcausingchanges at the translational level for the amino acid being encoded
The sickle cell mutation(passive) is caused byThe sickle cell mutation
a disease(passive) caused bya disease
an amino acid to be inserted which differs from that in a wild - type proteincausesan amino acid to be inserted which differs from that in a wild - type protein
the same amino acid to be inserted as was found in wild - typecausesthe same amino acid to be inserted as was found in wild - type
changes at the translational levelcausingchanges at the translational level
an amino acid to be inserted at that codon that differs from that in the wild typecausesan amino acid to be inserted at that codon that differs from that in the wild type
8 Sickle Cell Anemia(passive) Caused by8 Sickle Cell Anemia
to amino acid changesleadto amino acid changes
in amino acid substitutions or protein extension , duplications , deletions , and IS insertionresultingin amino acid substitutions or protein extension , duplications , deletions , and IS insertion
to changes in the amino acid sequence of a proteinleadto changes in the amino acid sequence of a protein
to amino acid change affecting enzyme functionleadingto amino acid change affecting enzyme function
a glutamic acid in the protein to be changed to a valine amino acidcausesa glutamic acid in the protein to be changed to a valine amino acid
in a different amino acid being placed at a specific position in a proteinresultin a different amino acid being placed at a specific position in a protein
in a change in the amino acid sequence of a polypeptidecould resultin a change in the amino acid sequence of a polypeptide
multiple amino acid changesmay causemultiple amino acid changes