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Qaagi - Book of Why

Causes

Effects

Oxidative stress ... the only mechanismto triggerautophagy

tumor cells(passive) caused byautophagy

ROS or oxidative stresscan provokeautophagy

the ability of mTOR inhibitorsto promptautophagy

the severity of oxidative stress(passive) is influenced byAutophagy

among other factors(passive) is triggeredAutophagy

The major factorsinfluencingautophagy

mycobacterial factorsinfluencingautophagy

ER stress and oxidative stress(passive) can be triggered byAutophagy

intermittent fasting and exercisecan causeautophagy

thus its abilityto triggerautophagy

the ability of JunBto preventautophagy

stress conditions(passive) is triggered byAutophagy

The ketogenic diet ... another wayto triggerautophagy

Starvation conditions that upregulatecauseautophagy

serum starvation and rapamycin(passive) triggered byautophagy

a Japanese scientist in 2016(passive) discovered byAutophagy

H2O2 in C2C12 cells(passive) caused byautophagy

Many factors , such as abnormal nutritional metabolism , oxidative stress , and agingcan causeautophagy

stress such as hypoxia and nutrient starvation(passive) is triggered byAutophagy

amino acid starvation , low cellular energy levels , withdrawal of growth factors , hypoxia , oxidative stress , endoplasmic reticulum ( ER ) stress , damaged cellular organelles and infection(passive) can be triggered byAutophagy

intermittent fasting ... that we know ofto triggerautophagy

the tissues and conditionstriggeringautophagy

starvation or MTOR inhibition in murine fibroblasts and epithelial cells(passive) caused byautophagy

either starvation or treatment with rapamycin(passive) can be triggered byautophagy

several of these predisposing factorscould ... influenceautophagy

numerous inflammatory factors ... some of whichcan triggerautophagy

to clean up damaged cells(passive) is designedAutophagy

while simultaneously starving the cellsto triggerautophagy

in the TRPML1-defective cellscould ... triggerautophagy

Adverse environmental conditions , such as nutrient depletion and oxidative stresscan causeautophagy

the ability of animal venomsto triggerautophagy

stress on cells by means of trainmay ... setautophagy

oxidative stress as a self - defense strategy(passive) can be triggered byAutophagy

a process capable of removing damaged / defective mitochondria(passive) is also triggeredAutophagy

the expression of autophagyrelated proteinsTo further confirm the enhanced ability of TIG1to influenceautophagy

Exercise also appearsto influenceautophagy

depriving the body of nutrients , which we can accomplish through intermittent fasting(passive) is triggered byAutophagy

under certain hostile conditions such as nutrient starvation , hypoxia , immune and hormone stimulation(passive) is triggeredAutophagy

during nutrient deprivation in cells as a homeostatic response to stress(passive) is triggeredAutophagy

increased cell death in some scenarioscausesincreased cell death in some scenarios

induced cell death in cancer cellscould contributeinduced cell death in cancer cells

to tumor cell deathcontributesto tumor cell death

in cell death [ 11may resultin cell death [ 11

a type of cell death(passive) caused bya type of cell death

to early cell deathleadingto early cell death

A549 cell death(passive) mainly caused byA549 cell death

proteotoxic cell deathpreventsproteotoxic cell death

to RDF cell deathcan leadto RDF cell death

to neuronal cell deathleadsto neuronal cell death

to increased cell death in CNS lymphomaleadingto increased cell death in CNS lymphoma

autophagic cell death in Tetrahymenapreventsautophagic cell death in Tetrahymena

cell death under certain conditionscan ... triggercell death under certain conditions

apoptotic cell death in several wayspreventsapoptotic cell death in several ways

ROS - mediated cell death ( apoptosis ) [ 99preventsROS - mediated cell death ( apoptosis ) [ 99

ROS - mediated cell death ( apoptosis ) [ 77preventsROS - mediated cell death ( apoptosis ) [ 77

ROS - mediated cell death ( apoptosis ) [ 80preventsROS - mediated cell death ( apoptosis ) [ 80

ROS - mediated cell death ( apoptosis ) [ 105preventsROS - mediated cell death ( apoptosis ) [ 105

to EGFR - targeted cancer cell deathleadingto EGFR - targeted cancer cell death

Lc - mediated cell death(passive) to be caused byLc - mediated cell death

hypoxia - induced cell deathto preventhypoxia - induced cell death

to BAC - induced cell deathspecifically contributesto BAC - induced cell death

pancreatic β cell deathpreventspancreatic β cell death

to cell death in pancreatic CSCsleadsto cell death in pancreatic CSCs

in Beclin1-dependent cell deathresultingin Beclin1-dependent cell death

cell death 138 virusesto triggercell death 138 viruses

in reduced apoptosis and cell death as depicted in Figresultingin reduced apoptosis and cell death as depicted in Fig

beneficial or harmful effects , such as cell survival or cell deathmay causebeneficial or harmful effects , such as cell survival or cell death

to cell starvation and ultimately apoptotic cell deathleadsto cell starvation and ultimately apoptotic cell death

cell death ... acting as an accessory to apoptosiscausescell death ... acting as an accessory to apoptosis

cell death ( autosis ... under certain conditionsmay ... causecell death ( autosis ... under certain conditions

to parasite cell death by a necrotic processleadto parasite cell death by a necrotic process

to caspase - independent macrophage cell deathcontributesto caspase - independent macrophage cell death

to formation of large autophagosomes and cell deathleadingto formation of large autophagosomes and cell death

tissue malfunction and necrotic cell deathcausestissue malfunction and necrotic cell death

cell death or improve tumor inhibitioncan causecell death or improve tumor inhibition

caspase - independent cell death [ 12can triggercaspase - independent cell death [ 12

to ING4-induced glioma cell deathcontributesto ING4-induced glioma cell death

to increased bortezomib - mediated cell deathleadingto increased bortezomib - mediated cell death

to cell death in nutrient - deprived ovariesTocontributesto cell death in nutrient - deprived ovariesTo

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