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Qaagi - Book of Why

Causes

Effects

with the non - technical marketer in mind(passive) is designedPersonyze

Rapamycincausesupregulation of autophagy

2- down - regulates Valosin - containing proteincausingimpaired autophagy

by the expression of mHTT(passive) caused bydysregulation of autophagy

the expression of mHTT(passive) caused bydysregulation of autophagy

by mutations in the gene(passive) caused bydeficient autophagy

by low ATP level(passive) caused byProtracted autophagy

low ATP level(passive) caused byProtracted autophagy

That inhibition of each Akt signaling andmay ... leadautophagy

The inhibition of the complex releases ULK1 from MTORC1resultingin autophagy

Inhibition of mTORcausesautophagy

The mTOR receptor is a sensor that monitorsintracellularoxygenand nutrient levels andactivatesautophagyin response to hypoxia , ER stressorstarvation ; the inhibition of mTOR activates the ULK complexalso resultingin autophagy

by the cardiac - specific deletion of autophagy - related protein 5 ( Atg5(passive) caused byautophagy

AMPK - mTORcan leadto autophagy

by Akt inhibition(passive) caused byautophagy

Dr. Yoshinori Ohsumi(passive) was discovered byAutophagy

autophagy and cancer nobel prizeDiscoveredAutophagy

Yoshinori Ohsumi in 2016(passive) discovered byAutophagy

cellular stress like starvation(passive) is caused byAutophagy

the ability of mTOR inhibitorsto promptautophagy

activated the ERK pathwayresultingin autophagy

The scientist ( Yoshinori Ohsumidiscoveredautophagy

autophagy nobel prizeDiscoveredAutophagy

in mammalian cells(passive) was discoveredAutophagy

medicine autophagyDiscoveredAutophagy

Jun Autophagy ... starvationleadsAutophagy

Yoshinori Ohsumi who won the Nobel Prize recently(passive) is discovered byAutophagy

by loss of LRRK2(passive) caused byautophagy

proteinsoriginatefrom autophagy

the various pathwaysto resultin autophagy

by COPI depletion(passive) provoked byabortive autophagy

pathwaysleadingto autophagy

This micro - environment acidification ... cellular stresswould leadto autophagy

by the loss of PTEN function(passive) caused byautophagy

starvation and hypoxia(passive) can be caused byAutophagy

the molecular processescontributingto autophagy

the molecular processesleadingto autophagy

Ohsumidiscoveredautophagy

Rapamycincausesautophagy

by rapamycin(passive) caused byautophagy

to NB progressioncontributedto NB progression

the same change(passive) caused bythe same change

to increased apoptotic cell death in the neonatal brainmay contributeto increased apoptotic cell death in the neonatal brain

towards the improvement ofcontributedtowards the improvement of

retention of VSVG at ERES ( Figcausedretention of VSVG at ERES ( Fig

retention of VSVG at EREScausedretention of VSVG at ERES

to cell survival , apoptosis or autophagic cell deathcan leadto cell survival , apoptosis or autophagic cell death

all players with 23 pointsledall players with 23 points

to enhanced resistance to oxidative stress and decreased cell deathleadsto enhanced resistance to oxidative stress and decreased cell death

migration defectscausingmigration defects

in the accumulation of defective organelles , including mitochondriaresultingin the accumulation of defective organelles , including mitochondria

excessive self - degradation leading to autophagic cell deathmay causeexcessive self - degradation leading to autophagic cell death

to the lysosomal degradation of cellular componentsleadsto the lysosomal degradation of cellular components

to oxidative stress - mediated autophagic cell deathcontributesto oxidative stress - mediated autophagic cell death

to the accumulation of damaged mitochondrialeadingto the accumulation of damaged mitochondria

to maintain cellular homeostasis through the removal of damaged cellular components in lysosomescontributesto maintain cellular homeostasis through the removal of damaged cellular components in lysosomes

in aggregation of ubiquitinated prone proteins and subsequent ER stress - associated cell deathresultsin aggregation of ubiquitinated prone proteins and subsequent ER stress - associated cell death

to the mitochondrial dysfunction and cell deathcan leadto the mitochondrial dysfunction and cell death

to neurodegeneration induced by mitochondria dysfunctionat least partially ... contributesto neurodegeneration induced by mitochondria dysfunction

to apoptotic death of the cellsleadingto apoptotic death of the cells

to cell death AutophagyDoes ... contributeto cell death Autophagy

to less degradation of protein aggregates in the cellleadsto less degradation of protein aggregates in the cell

to accumulation of damaged mitochondrialleadingto accumulation of damaged mitochondrial

to cell death in glioma cellsleadingto cell death in glioma cells

ROS production and A ( 1 - 42 ) degradation in lysosomesmay influenceROS production and A ( 1 - 42 ) degradation in lysosomes

to apoptotic cell death through inhibition ofleadsto apoptotic cell death through inhibition of

to accumulation of dysfunctional mitochondria , ERleadsto accumulation of dysfunctional mitochondria , ER

to bulk degradation of both cytoplasmic and mitochondrial damagecontributesto bulk degradation of both cytoplasmic and mitochondrial damage

in cellular adaptation , as well as cell survival or cell deathcan resultin cellular adaptation , as well as cell survival or cell death

to the maintenance of cellular protein and organelle homeostasisalso contributesto the maintenance of cellular protein and organelle homeostasis

to degradation of proteinsleadsto degradation of proteins

to maintaining the metabolic balance of cells , which is a mechanism of cell self - protectioncontributesto maintaining the metabolic balance of cells , which is a mechanism of cell self - protection

to muscle protein degradationmay contributeto muscle protein degradation

to cell death in cancerleadingto cell death in cancer

to maintaining cellular homeostasis as a result of quality control of both proteins and organellescontributesto maintaining cellular homeostasis as a result of quality control of both proteins and organelles

to both survival and cell deathcontributesto both survival and cell death

to protein accumulation and neurotoxicityleadingto protein accumulation and neurotoxicity

to cancerous tumorsleadingto cancerous tumors

to senescent cell accumulationDoes ... contributeto senescent cell accumulation

to apoptotic cell deathleadsto apoptotic cell death

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