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Smart Reasoning:

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Qaagi - Book of Why

Causes

Effects

by EGFR up - regulation(passive) might be caused byEGFR inhibitors

Denali(passive) contributed byRIPK1 Inhibitors

Administration ofresultsVEGF inhibitors

RASleadBRAF inhibitors

to limit the effects of a cell structure called a proteasome(passive) are designedProteasome inhibitors

to target cancers that already have existing defects in DNA repairs(passive) are designedPARP inhibitors

effortsto discovernonpeptide inhibitors

Coadministration of desloratadine withresultsCYP3A4 inhibitors

to prevent cancer cells from repairing their damaged DNA(passive) are designedPARP inhibitors

to kill cancer cells by exploiting defects in a tumor DNA repair pathway(passive) are designedPARP inhibitors

by our generic cialis(passive) directly caused byPde5 inhibitors

to specifically treat tumors with faulty BRCA1 and BRCA2 genes in breast and ovarian cancers(passive) have been designed PARP inhibitors

to specifically treat tumors with faulty BRCA1 and BRCA2 genes in breast and ovarian cancers(passive) have been designedPARP inhibitors

inactivation of SLFN11(passive) caused byPARP inhibitors

to regulate glucose by manipulating a protein found in the renal system(passive) are designedSGLT2 inhibitors

to treat patients with persistently high LDL - C levels despite optimal use of statins(passive) are designedPCSK9 inhibitors

which used covalent docking techniquesto prospectively discoverJAK3 inhibitors

a targeted programto discoverPARG inhibitors

to keep the protein from performing its function(passive) are designedSGLT2 inhibitors

to work with the statin class of cholesterol - reducing drugs(passive) are designedPLA2 inhibitors

to stop the repair process in cancer cells , leaving the damaged cells to die(passive) are designedPARP inhibitors

to control diabetes by blocking reabsorption of glucose by the kidneys , impacting normal kidney function and allowing more sugar to be passed from the body through urine(passive) are designedSGLT2 inhibitors

discharge of [ 3H]dopamine ... the facthave discoveredVMAT2 inhibitors

for treatment of human immunodeficiency virus-1 ( HIV-1(passive) were initially designedDDX3 inhibitors

The introduction of high - dose therapy , especially , and autologous stem cell transplantation , as well as the development of new drugs , such as immunomodulatory drugs ( IMiDs ) andhave contributedproteasome inhibitors

introduction of high - dose therapy , especially , and autologous stem cell transplantation , as well as the development of new drugs , such as immunomodulatory drugs ( IMiDs ) andhave contributedproteasome inhibitors

to increased vascular tone related to decreased nitric oxide productioncan leadto increased vascular tone related to decreased nitric oxide production

to an increase in D - dimer levelscontributeto an increase in D - dimer levels

alsomight ... leadalso

vascular regulation defects within cancers peoplecausevascular regulation defects within cancers people

in an increase in fentanyl plasma concentrations , which could increase or prolong both the therapeutic and adverse effectsmay resultin an increase in fentanyl plasma concentrations , which could increase or prolong both the therapeutic and adverse effects

to vascular thrombosiscan leadto vascular thrombosis

proteinuria(passive) caused byproteinuria

retinal atrophymay ... causeretinal atrophy

TMAcan causeTMA

hypothyroidismcan causehypothyroidism

to substantial increases in trazodone plasma concentrations with the potentialmay leadto substantial increases in trazodone plasma concentrations with the potential

to substantial increases in trazodone plasma concentrations with the potential for adverse effectsmay leadto substantial increases in trazodone plasma concentrations with the potential for adverse effects

cerebrovascular events either by elevating systemic blood pressure or by damaging the cerebral vascular endotheliummight causecerebrovascular events either by elevating systemic blood pressure or by damaging the cerebral vascular endothelium

in several - fold increase in the plasma concentration of sildenafilresultedin several - fold increase in the plasma concentration of sildenafil

hyperactivation of the MAPK pathway in BRAF wild - type cells including T - cellscausehyperactivation of the MAPK pathway in BRAF wild - type cells including T - cells

in a number of - fold increase in the plasma concentration of sildenafilresultedin a number of - fold increase in the plasma concentration of sildenafil

possiblymay ... leadpossibly

to increased concentration of solifenacin succinateleadingto increased concentration of solifenacin succinate

in a fatal overdose of fentanyl from fentanyl transdermal systemcan resultin a fatal overdose of fentanyl from fentanyl transdermal system

to increased tacrolimus blood levelspotentially leadingto increased tacrolimus blood levels

in a number viagraresultedin a number viagra

to inhibition of cell growth and even cell deathcan leadto inhibition of cell growth and even cell death

to inhibition of cell proliferationleadsto inhibition of cell proliferation

the diseasedo ... causethe disease

significant cutaneous adverse reactionsfrequently causesignificant cutaneous adverse reactions

BRAF and PTEN mutant melanoma cells to increase levels of fibronectincauseBRAF and PTEN mutant melanoma cells to increase levels of fibronectin

to a trial in humansledto a trial in humans

typicallyresulttypically

Management(passive) is caused byManagement

multiple , disseminated lesionscan causemultiple , disseminated lesions

physiology(passive) caused byphysiology

the NCIC CTG clinical trials groupledthe NCIC CTG clinical trials group

an increase in PD-1 expression ... emphasizing the requirement for combinatorial approachescausedan increase in PD-1 expression ... emphasizing the requirement for combinatorial approaches

psychological symptoms such as irritability , anxiousness , insomnia , hallucinations , aggression , depression , and suicidal thinking or behaviorcan causepsychological symptoms such as irritability , anxiousness , insomnia , hallucinations , aggression , depression , and suicidal thinking or behavior

Low stomach prostanoid levels(passive) caused byLow stomach prostanoid levels

the loss of constitutive phosphorylation on serine residues 910 and 935causethe loss of constitutive phosphorylation on serine residues 910 and 935

slow - binding inhibition of serine and cysteine proteasesoften causeslow - binding inhibition of serine and cysteine proteases

inhibition of CFTR - independent chloride currents ( 55 ) , cellular toxicity ( 55 ) , increased production of reactive oxygen species , and reduction of mitochondrial membrane potential ( 56causeinhibition of CFTR - independent chloride currents ( 55 ) , cellular toxicity ( 55 ) , increased production of reactive oxygen species , and reduction of mitochondrial membrane potential ( 56

psychotic symptoms and cognitive dysfunctionscould causepsychotic symptoms and cognitive dysfunctions

the metal dissolution reaction they tend to be sensitive to the nature of the metalinfluencethe metal dissolution reaction they tend to be sensitive to the nature of the metal

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