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Qaagi - Book of Why

Causes

Effects

a physical injurycausesa release of ATP from injured cells

Overactivation of PARPcausesATP depletion , leading to cell necrosis

These ratios ... importantto preventcells undergoing apoptosis due to ATP depletion

PARP-1 ... is knownto causedeleterious ATP depletion in necrotic cells

Xl Exposed particularly is changedcausinga depletion in cell ATP

environmental stressescauseATP depletion in cells

Indeed , fructose has been shownto causeATP depletion in humans[62,63

the brain cellsthereby preventingATP depletion mediated cell death

HGFpreventsATP - depleted mIMCD-3 cell release

Fructose is distinct from other sugarscan ... causeATP depletion in cells

to lysis and cell death ( necrosisleadsto lysis and cell death ( necrosis

to all of the following except Loss of function of Na / K ATPaseleadsto all of the following except Loss of function of Na / K ATPase

thusmay ... leadthus

to the activation of P2-type and adenosine receptors upon extracellular ATP catabolism by ecto - nucleotidases [ 51leadsto the activation of P2-type and adenosine receptors upon extracellular ATP catabolism by ecto - nucleotidases [ 51

pain by activation of ATP receptors on specialized nerve endingscausespain by activation of ATP receptors on specialized nerve endings

to cell lyses and cell deathleadsto cell lyses and cell death

ductal Cl− reabsorption via activation of P2Y2 receptors and CFTR Cl− channelscausesductal Cl− reabsorption via activation of P2Y2 receptors and CFTR Cl− channels

to the increased concentration of adenosine found in the airway surface liquid of asthmatic patientscontributesto the increased concentration of adenosine found in the airway surface liquid of asthmatic patients

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