targeting multiple water - mediated interactions between the target protein and small - molecule inhibitors(passive) were rationally designed byMMP-13 ) inhibitors

high - throughput screening of 40,967 compounds(passive) were ... discovered byNS4A inhibitors

to increase levels of high - density lipoprotein ( HDL ) cholesterol - which is sometimes described as ' good ' cholesterol with a protective cardiovascular effect although that hypothesis has been dented by the CETP class failures(passive) are designedCETP inhibitors

to help folks with high levels of dangerous cholesterol who ca n’t get their situation beneath control with statins such as Pfizer Inc. ’s Lipitor(passive) are designedPCSK9 inhibitors

to break down endocannabinoids , including anandamide , in the brain and are also being investigated for use in the treatment of chronic pain(passive) are designedFAAH inhibitors

to break down endocannabinoids , including anandamide , in the brain and are being investigated for use in the treatment of chronic pain(passive) are designedFAAH inhibitors

3D QSAR pharmacophore modeling Raj Kumar , Minky Son(passive) discovered byAKR1B10 inhibitors

based on dioxabicyclo[3.2.1 ] octane with the aim to search new lead molecule(passive) were designedSGLT2 inhibitors

to slow the inactivation of incretin hormones GLP-1 ( glucagon - like peptide-1 ) and GIP ( glucose - dependent insulinotropic peptide(passive) are designedDPP-4 inhibitors

cocrystallography and scaffold - based drug design New IGF drug stirs competition in growth factor segment(passive) discovered byphosphodiesterase inhibitors

protein - protein interactions ... extremely challengingto designHIF-1α inhibitors

Recent methodological changes and the risks and benefits of vitamin D supplementation , Critical Reviews in Clinical Laboratory Sciences , 2016 , 53 , 1 , 13 CrossRef 5 Omar Abdel - Rahman , Denosumab versus zoledronic acidto preventaromatase inhibitors

to be screened against the Molecular Libraries Small Molecule Repository ( MLSMRto discoverTDP-43 inhibitors

fragment - based screening Angeline C.-H. Lee , Pondy Murugappan Ramanujulu , Anders Poulsen , Meredith Williams , Stéphanie Blanchard , Diana M. Ma(passive) discovered byPDK1 inhibitors

to either foil enzyme activity and therefore viral dsDNA integration(passive) are designedIntegrase inhibitors

cocrystallography and scaffold - based drug design by Zhang , Kam Y J and Schlessinger , Joseph and Kim , Sung - Hou and Gillette , Sam and Suzuki , Yoshihisa and Artis , Dean R and Blasdel , Landy and Ibrahim , Prabha N and Zhang , Chao and Milburn , Michael V and Card , Graeme L and Fong , Daniel and Bollag , Gideon and England , Bruce P Nature Biotechnology , ISSN 1087 - 0156(passive) discovered byphosphodiesterase inhibitors

Previous attempts to develop Ku / DNA - PK inhibitors , ATR / CHK1 inhibitors , andhave resultedRad51 inhibitors

to inhibit the action of the enzyme aromatase , which converts androgens into estrogens within the body(passive) are designedAromatase inhibitors

to block an enzyme involved in the production of oestrogen , which fuels the growth of most breast cancers(passive) are designedAromatase inhibitors

to block bile acid reabsorption in the ileum and increases faecal bile acid excretion(passive) are designedASBT inhibitors

Tanaka , T. , Nakazawa , H. , Kuriyama , N. , KanekipreventM."Farnesyltransferase inhibitors

of two aromatic rings and a linker(passive) are typically composedamyloidogenesis inhibitors

to slow the inactivation of incretin hormones glucagon - like peptide-1 ( GLP ) GLP-1 and glucose - dependent insulinotropic peptide ( GIP(passive) are designedDPP-4 inhibitors

such as triptolide [ 30 ] , emetine , klugine , isocephaeline [ 31 ] , manassantin B , 4-o - demethylmanassantin [ 32 ] , alpinumisoflavone and 4-O - methyl alpinumisoflavone [ 9(passive) were discoveredHIF-1 inhibitors

to bar the critical enzyme aromatase , which turns androgen into oestrogen to begin with(passive) have been discoveredAromatase inhibitors

To test the effectiveness of denosumab in preventing bone losscausedbyaromatase inhibitors

to block the body 's production of estrogen , thereby preventing the hormone from stimulating tumor growth(passive) were designedThe aromatase inhibitors

to inhibit the proto - oncoprotein Ras , which acts as a critical signaling node in many growth factor signaling pathways ( 5(passive) were initially designedFTase inhibitors

to remove oestrogens from the blood thus removing some of the fuel necessary for breast cancer growth(passive) are designedAromatase inhibitors

to block HIV 's ability to replicate once it has entered a T cell 's nucleus(passive) are designedIntegrase inhibitors

to prevent viral DNA integration into the host cell genome(passive) are designedIntegrase inhibitors

to an enzyme involved in the Merck & Co(passive) are designedBACE inhibitors

the immuno - oncologysettingRIPK1 inhibitors

Chemical inhibition of apyrase activity by the application ofresultsapyrase inhibitors

to reduce blood glucose(passive) are designedSGLT2 inhibitors

to apply the brakes to uncontrolled glucose resorption by the kidneys in patients with diabetes(passive) were designedSGLT2 inhibitors

synthesizing arginine analogue that targets the arginine containing peptide binding site or by synthesizing AdoMet and arginine analogues ( bisubstrate analogue ) that target the AdoMet and substrate binding pockets(passive) are discovered byPRMT inhibitors

Hormone therapy , tamoxifen in premenopausal women , andresultthe aromatase inhibitors

to treat various serious diseases such as breast cancer in women and gynecomastia in men(passive) are medically designedAromatase inhibitors

A combination of ERK- andpreventp38-MAPK inhibitors