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Qaagi - Book of Why

Causes

Effects

local immune responsescontributeto the antibody responses in chronic graft rejection

the hostleadingto the rejection of the transplant through antigen - antibody reaction

this is thoughtto contributeto the development of antibody - mediated rejection

inhalationcausesbronchodilation by antigen antibody reaction

immune effector cellscontributeto tumor rejection by therapeutic antibodies

which immune effector cellscontributeto tumor rejection by therapeutic antibodies

to HLA antigenscan causeacute antibody - mediated rejection ( AMR

The presence of multiple risk factorscausesearly antibody - mediated rejection

donor specific antibodieswould causehyperacute rejection or acute antibody - mediated rejection

anti - HLA antibodiescan causehyperacute or acute antibody - mediated rejection

Donor - specific alloantibodies ( DSA ) to HLA - DPmay causeantibody - mediated rejection ( AMR ) , especially in

recipient 's B - lymphocytes which produce alloantibodies against donor(passive) is caused byantibody - mediated ) type of rejection

specific antibodieswould causehyperacute rejection or acute antibody - mediated rejection

antibodies ( Abs ) directed against HLAs(passive) is ... caused byAntibody - mediated rejection ( AMR ) in renal allografts

the antibodieswould leadto hyperacute rejection or acute antibody - mediated rejection

as the clinical rejectionleadsto chronic antibody - mediated rejection

chiefly(passive) is ... causedAntibody - mediated rejection of transplanted lungs

the proliferation of B cells and the production of donor - specific antibodiescontributeto antibody - mediated organ rejection

The presence of donor - specific antibodies ( DSAleadsto antibody - mediated rejection ( AMR

by anti - donor HLA antibodies(passive) caused byantibody - mediated rejection ( AMR

anti - donor HLA antibodies(passive) caused byantibody - mediated rejection ( AMR

epigenetic modifications ... its induction , selection and subsequent passagescan causeimmuno - incompatbility to bring about rejection

the particular relative risk ofresultwith regard to antibody - mediated rejection

permeation of immunoglobulinscan causeantibody - mediated rejection of embedded hepatocytes

antidonor antibodies(passive) caused byantibody - mediated rejection ( AMR

by antidonor antibodies(passive) caused byantibody - mediated rejection ( AMR

HLA and non - HLA antibodies and developing non - invasive immune monitoring assays using gene or protein expression patterns(passive) caused byunderlying antibody mediated rejection

by donor specific anti - human leukocyte antigen antibodies ( HLA - DSA(passive) caused byAntibody - mediated rejection

HLA - specific antibodiesmay leadto hyperacute antibody - mediated rejection

that Belatacept or anti - CD40 mAb combined with lymphodepletion suppressed the humoral responseledto the prevention of antibody - mediated rejection

by T cells(passive) is caused byRejection that is caused by antibody

antibodies that are likelyto causeantibody - mediated rejection

Immunosuppression reduction and interferon treatmentmay resultin antibody - mediated rejection

by primary sensitization(passive) caused byantibody - mediated rejection

the factorsinfluenceantibody - mediated cytotoxicity

by the presence of foreign cells and different major histocompatibility complexes ( MHC(passive) can be caused byimmune rejection

epitopes that are likelyto resultin antibodies and rejection

the genes responsible for the proteins on cellscauseimmune rejection

MHC protein differences between the donor and the patient ( recipient(passive) is caused byImmune rejection

cellscauseimmune rejection

in graft lossresultedin graft loss

Transplant rejection(passive) is caused byTransplant rejection

to graft lossleadingto graft loss

to failures soon after transplantation ( Txhave ledto failures soon after transplantation ( Tx

in the loss of the kidney graftresultsin the loss of the kidney graft

to allograft failureleadingto allograft failure

in allograft failuremay resultin allograft failure

Food allergies(passive) are caused byFood allergies

early graft loss(passive) caused byearly graft loss

to livercontributeto liver

from different molecular processesresultfrom different molecular processes

Early Rejection(passive) Caused byEarly Rejection

to destroy the cells which trigger rejectionare designedto destroy the cells which trigger rejection

in permanent loss of the graft function even before transplant surgery is completedcan resultin permanent loss of the graft function even before transplant surgery is completed

60 percent of all transplanted kidney failurescauses60 percent of all transplanted kidney failures

reactionscausingreactions

Type II Hypersensitivity Type II hypersensitivity or cytotoxic hypersensitivity(passive) is caused byType II Hypersensitivity Type II hypersensitivity or cytotoxic hypersensitivity

to virus clearance and a functional curecan leadto virus clearance and a functional cure

in slowly declining antibody responses that last for decadesresultin slowly declining antibody responses that last for decades

to a massive accumulation of shallow clathrin - coated pits on the presynaptic plasma membraneledto a massive accumulation of shallow clathrin - coated pits on the presynaptic plasma membrane

chronic rejectioncauseschronic rejection

to chronic rejectionleadingto chronic rejection

graft damage(passive) caused bygraft damage

to graft failureleadingto graft failure

in allograft failuremay resultin allograft failure

to graftleadingto graft

activation of complement cascadecausingactivation of complement cascade

graft dysfunction and chronic rejection , the leading cause of death among transplant patientscan causegraft dysfunction and chronic rejection , the leading cause of death among transplant patients

to the development of acute cellular rejectionleadingto the development of acute cellular rejection

to graft versus host diseaseleadingto graft versus host disease

fetal deathcausingfetal death

Acute kidney graft rejection(passive) caused byAcute kidney graft rejection

to organ failurecan leadto organ failure

to the discover of acquired immune toleranceledto the discover of acquired immune tolerance

in a loss of self - controlresultedin a loss of self - control

his hand to become intolerable to live withhad causedhis hand to become intolerable to live with

agglutination(passive) caused byagglutination

with transplants from other sourcescan resultwith transplants from other sources

the monkey to die within nine dayscausedthe monkey to die within nine days

the monkey to die after nine dayscausedthe monkey to die after nine days

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