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CDR sequencesdo ... resultin reduction of antibody - antigen binding activity
the protein chainleadingto a reduction of the strength of the antibody - antigen interaction
However , this can not be advantageousresultsin loss of antigen binding by the antibody conjugate
likelyto leadto rapid antibody re - binding upon dissociation
However , this may not be advantageousresultsin loss of antigen binding by the antibody conjugate
Therefore , not only the interactions with IgG - Fc but also with IgG - Fab should be consideredwhen designinga new affinity ligand for IgG purification
those supplementary wash stepscan promptelution of some target antibody ... reducing yield
Antibody humanizationmay resultin decreased antigen - antibody binding affinity
The mechanismscontributeto protection by NA - binding antibodies
IVIgcausesa rapid reduction of antibodies
Statistical methods identified which changed amino acidscauseda reduction in antibody binding
novel protocolsdesignedto reduce anti - donor antibodies
quality control techniques(passive) are designedAll processes for antigen and antibody purification and
This observationledto the purification of cTnT , the generation of monoclonal antibodies
trafficking between the Golgi / trans - Golgi network ( TGN ) and folate - containing endosomesmight contributeto disulfide bond reduction
the opportunityto contributeto downstream purification process development of monoclonal antibodies
orderto causebinding - inhibitory antibodies
ammonium thiocyanate as described before with a slight modification(passive) caused byantibody - antigen binding
this original approachledto a dramatic reduction in the binding of the antibody
a new Protein A chromatography resindesignedfor the purification of monoclonal antibodies ( mAbs
These drugsmay leadto reduced production of IgG antibodies
M. B. van Eldijk , F. C. M. Smits , J. C. Thies , J. Mecinovic , J. C. M. van Hest , Thermodynamic investigation of Z(33)-antibody interactionleadsto selective purification of human antibodies
using biotinylated supplementary antibody implemented by avidin - biotin - horseradish peroxidase complicated ( ABC ) , and 3,3-diaminobenzidine ( Sprinkle ) substrate ( all from Vector Laboratory(passive) had been discoveredAntibody - antigen processes
monomeric antibodies are separated from the aggregatesthereby resultingin purification of monomeric antibodies
in reduced non - specific bindingresultingin reduced non - specific binding
to joint inflammation in rheumatoid arthritis ( RAleadsto joint inflammation in rheumatoid arthritis ( RA
in specific , saturable heparin bindingresultedin specific , saturable heparin binding
of two heavy chainscomposedof two heavy chains
alsocan ... contributealso
to the formation of immune complexes whose structure is evaluated after stainingleadsto the formation of immune complexes whose structure is evaluated after staining
the effect(passive) was caused bythe effect
in a low HCP levelcan resultin a low HCP level
alsohas ... contributedalso
to a high recovery of activityleadsto a high recovery of activity
in high specificity and low background signalresultingin high specificity and low background signal
their apoptosiscausestheir apoptosis
the cell to divide rapidly ( clonal expansion ... its progeny differentiate into memory B cells and effector B cells called plasma cellscausesthe cell to divide rapidly ( clonal expansion ... its progeny differentiate into memory B cells and effector B cells called plasma cells
in the same staining pattern observed in panel B ( data not shown ) , which confirms the specificity of the reactionresultedin the same staining pattern observed in panel B ( data not shown ) , which confirms the specificity of the reaction
in low background signalresultingin low background signal
to the functioning of the Fc region of antibodyleadsto the functioning of the Fc region of antibody
the cell to divide rapidly ( clonal expansioncausesthe cell to divide rapidly ( clonal expansion
cross - linkingcausescross - linking
in improvement of cardiac function and decrease in myocardial inflammationresultedin improvement of cardiac function and decrease in myocardial inflammation
Defective T - cell proliferative responses to mitogens , and(passive) may ... be causedDefective T - cell proliferative responses to mitogens , and
the closed Env confirmation(passive) caused bythe closed Env confirmation
in highly purified MAbsresultedin highly purified MAbs
Autoagglutination(passive) is caused byAutoagglutination
decreased sensitivity(passive) caused bydecreased sensitivity