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Qaagi - Book of Why

Causes

Effects

partial unfolding Monoclonal antibodies ( mAbs(passive) could be triggered byAntibody aggregation

contains bovine serum albumin ( BSAto preventantibody aggregation

partial unfolding of its domains(passive) could be triggered byAntibody aggregation

The hydrophobicity of the drugcausesaggregation of the antibody

dexamethasone phosphate and betamethasone phosphatepreventantibody aggregation

exposure to peroxide(passive) caused byantibody aggregation

the different pathways and energy changesresultin antibody aggregation

Incorrect disulfide bond formation or exchange ... longterm mAb storagecan causeantibody aggregation

topical compositionspreventingantibody aggregation

a number of factors , such as the addition of incompatible chemicals including organic solvents(passive) is triggered byAntibody aggregation

modification of the antibody carrier composition ... usedto preventantibody aggregation

the appropriate environmentto preventantibody aggregation

HCPs 8:40 FactorsInfluencingBiotherapeutic Monoclonal Antibody Aggregation Aggregation

in the right ratiosto causein the right ratios

massive activation of the complement pathway , leading to severe , even fatal , anaphylaxiscan triggermassive activation of the complement pathway , leading to severe , even fatal , anaphylaxis

many problems such as not injecting the proper dose , due to a decrease in the protein ’s concentration , or causing immunogenic responses that may affect the safety or efficacy of the drug potentially causing harm to patientscan causemany problems such as not injecting the proper dose , due to a decrease in the protein ’s concentration , or causing immunogenic responses that may affect the safety or efficacy of the drug potentially causing harm to patients

the clustered arrangement of gold particles(passive) was caused bythe clustered arrangement of gold particles

the accumulation of gold particles(passive) is caused bythe accumulation of gold particles

to the strong agonistic activity of 3H3-derived Abscould contributeto the strong agonistic activity of 3H3-derived Abs

more about diseases related to APRIL / TNFSF13 Antibody ( IC8843NDiscovermore about diseases related to APRIL / TNFSF13 Antibody ( IC8843N

related pathways , diseases and genes to Aldo - keto Reductase 1C4 /Discoverrelated pathways , diseases and genes to Aldo - keto Reductase 1C4 /

EphA2 internalizationcausesEphA2 internalization

to such signaling modemay contributeto such signaling mode

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