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that all of the candidate somatic mutations consisting of single nucleotide substitutions were predictedto resultin changes in the amino acid sequence by direct nucleotide sequence analysis
The list of pathogenic organisms , such as viral , bacterial , fungal , spirochete , and protozoa antibodiesmay contributeto tissue - specific thyroid autoimmunity via antibody amino acid sequence homology
These mutationscausesmall changes in the protein sequence of antibodies and lead to increased antibody affinity for specific antigens
None of these substitutionscausedchanges in the putative amino acid sequence of the E protein
different stabilizing forcesresultingfrom interactions between the side - chain groups of the amino acid sequence
This deletioncauseda frameshift leading to change in the amino acid sequence
V ( variable ) domainis composedof amino acid sequences that define each type of antibody and their binding affinity to an antigen
Food allergiescausean immediate reaction trigger type IgE antibodies
sequence variationscauseamino - acid sequence changes ( non - synonymous SNPs
As an enzyme , AID induces mutations and recombination in immunoglobulin genesleadingto increased antibody affinity for antigen and alterations in antibody - effector function
This mutationleadsto an rh amino acid change in protein sequence
Mutations happen at the DNA levelsometimes causingchanges in the amino acid sequence of a protein
Certain human diseases ... mutationscausechanges in the amino acid sequence of a protein
nonsynonymous mutationscan causeamino acid changes in the protein sequence
to considerwhen designingpeptide sequence for successful antibody production
Immuonogenic peptide - carrier complexes stimulate immune responseshopefully resultingin the desired outcome of producting specific antibodies directed against the amino acid peptide sequence
a unique antigen recognition site ( epitopecomposedof amino acid sequences different from other commercially available antibodies targeting the same antigen
This mutationcauseda leucine to proline change in the amino acid sequence
only 12 interacting residue pairscontributeto over 40 % of the interaction energy in antibody - antigen interactions
highly specific domainsare designedto recognize certain amino acid sequences ( antigens ) in other proteins
a mutationleadingto an amino acid change alters the peptide sequence
The regression modelledto the definition of amino acid - associated weights ( AAWS ) as predictors of antibody - peptide reactivity
Out of the 1,267 variations , 344 were non - synonymousresultedin an amino acid change in the encoded peptide sequence
Antigen signalsoriginatingfrom amino acids involved in the interaction with the antigen binding peptide
a unique antigen recognition site ( epitope ) ,composedof amino acid sequences different from other commercially available antibodies
none of themcauseda change in the derived amino acid sequence
Other mutations can be neutral ... , but the protein still functions similarly with the new amino acid e.leadto amino acid sequence changes
This mutation ... is predictedto causeamino acid sequence changes
Mutation For many drug targetscan resultamino acid sequence changes
by the mutations(passive) caused byAmino acid sequence changes
Antigen signalsoriginatingfrom amino acids involved in the interaction with the antigen binding polypeptide
those residuescontributemost significantly to the energetics of antibody - antigen interaction
that this hydrophobicity will be taken into accountwhen designingalterations in the amino acid sequence of a zvegf4 polypeptide
precipitationresultingfrom interaction of specific antibody and antigen
any known methodcausesmutation in an amino acid sequence
S gene mutationsmay causeamino acid substitutions in surface antigens
the active partcausesinteraction of every antibody
a high background signalresultedfrom the nonspecific interactions of the fluorescent antibodies
a systemic inflammatory responseresultingfrom antigen - antibody interactions
Can you helpdesigna peptide sequence for my antigen
in amino acid substitutionsresultsin amino acid substitutions
AP(passive) is caused byAP
highly specific domains(passive) are designedhighly specific domains
to defective signalingwould leadto defective signaling
to unique biological phenomenaleadto unique biological phenomena
in a reduced affinityresultedin a reduced affinity
alsomay ... resultalso
in loss of function or gain of function for the resulting ferroportin proteincan resultin loss of function or gain of function for the resulting ferroportin protein
these antibiotic reactionscausethese antibiotic reactions
Such interference(passive) can be caused bySuch interference
to unique biological phenomenaleadto unique biological phenomena
reactionto causereaction
to unique biological phenomenaleadto unique biological phenomena
in antigen - antibody immune complexresultingin antigen - antibody immune complex
to reliable estimation and ranking of antibodies in their affinity for the antigenleadto reliable estimation and ranking of antibodies in their affinity for the antigen
A conformational epitope(passive) is composedA conformational epitope
in an increase in potency [ 1,2may resultin an increase in potency [ 1,2
to structural variation in the variable regionleadsto structural variation in the variable region
in heteroclitic peptides ... peptide analogs substituted at positions other than MHC contact residuesresultedin heteroclitic peptides ... peptide analogs substituted at positions other than MHC contact residues
to the development of a variety of immunologic assays , which can be used to detect the presence of either antibody or antigenhas ledto the development of a variety of immunologic assays , which can be used to detect the presence of either antibody or antigen
to the development of a variety of immunologic assays , which can be used to detect the presence of either antibodyhas ledto the development of a variety of immunologic assays , which can be used to detect the presence of either antibody
to different versions of an enzyme migrating different distances in an electrophoretic gelcan leadto different versions of an enzyme migrating different distances in an electrophoretic gel
in a change in the amino acid sequenceresultsin a change in the amino acid sequence
to the development of a variety of immunologic assayshas ledto the development of a variety of immunologic assays
in more spacious interfaces where the space could be occupied by the water moleculesmight resultin more spacious interfaces where the space could be occupied by the water molecules
to complement activationcan leadto complement activation
in this reactionresultsin this reaction
false positives due to cross - reactivitycausefalse positives due to cross - reactivity
false positivescausefalse positives
experimental animals(passive) provoked byexperimental animals
altered downstream signalingmay causealtered downstream signaling
agglutinationcausesagglutination
to cysteinedesignedto cysteine
24 Agglutination Agglutination - Clumping of blood cells(passive) caused by24 Agglutination Agglutination - Clumping of blood cells
to release of allergic mediators , which causes injury 1leadsto release of allergic mediators , which causes injury 1
from viral proliferation in the overlying epithelium.10,12 Anterior stromal keratitisresultingfrom viral proliferation in the overlying epithelium.10,12 Anterior stromal keratitis
in partial hemagglutination or irregular shapes of RBC precipitation , which is quite often seen with avian origin RBCsresultingin partial hemagglutination or irregular shapes of RBC precipitation , which is quite often seen with avian origin RBCs