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For one , dopaminergic neurons show abnormalities in mitochondrial complex 1causingaggregation of alpha - synuclein
cytosolic cofactors in disease pathogenesis ... molecular targetsto influencealpha - synuclein aggregation
Neuron - to - neuron transmission of a - synucleinmay causealpha - synuclein aggregates
this compoundwould ... influencealpha synuclein aggregates
the screening of large chemical libraries in search of inhibitorscan ... preventalpha - synuclein aggregation
Lipid vesiclestriggeralpha - synuclein aggregation
Prof Brundin wants to prove that MSDC-0160 improves mitochondrial activity and stops the pathways associated with Parkinson ’spreventingalpha synuclein aggregation
the factorstriggeraggregation of alpha - synuclein
that DJ-1 acts as a chaperone or chaperone regulator ; increasing DJ-1 expression increases levels of Hsp70preventingaggregation of alpha
an omega-3-linked pathwayleadingto alpha - synuclein aggregation
small molecule inhibitors of tissue transglutaminasecan preventalpha - synuclein aggregation
implications for researchers tryingto preventalpha - synuclein aggregation
methamphetamine exposure in PC12 cells(passive) caused byalpha - synuclein aggregation
Test the efficacies of small peptidesto preventalpha synuclein aggregation
Small heat - shock proteinspreventalpha - synuclein aggregation
Parkinson ’s Disease Status ... Two novel small moleculesto preventalpha - synuclein aggregation
global levels of O - GlcNAc which could subsequently helppreventalpha synuclein aggregation
SHSY-5Y neuroblastoma cells were treated with 100µM copperto causealpha - synuclein aggregation
a potential site that might be exploitedto preventalpha - synuclein aggregation
a highly promising immunogenmay preventthe alpha synuclein aggregation
Prefoldinpreventsaggregation of alpha - synuclein
drugswill preventaggregation of alpha synuclein
I do n’t knowmight leadto alpha - synuclein aggregation
three different nanoparticles : gold nanoparticles which have been shownto preventalpha - synuclein aggregation
Curcuminpreventsaggregation of alpha - synuclein
toxicityresultingfrom alpha - synuclein aggregation
hsc70 alterationpossibly contributingto alpha - synuclein aggregation
PBT 434 ... an excellent drug candidateto preventalpha - synuclein aggregation
In cultured neurons , iron has been shownto causeaggregation of alpha synuclein [ 70–73
A viruscausesalpha - synuclein aggregation
reduced GCase activityleadsto alpha - synuclein aggregation
to enhance the mitochondrial dysfunction , which might be a key factor in the pathogenesis of PD.[1may contributeto enhance the mitochondrial dysfunction , which might be a key factor in the pathogenesis of PD.[1
to various cellular disorders including microtubule impairment , synaptic and mitochondrial dysfunctions , oxidative stress as well as dysregulation of Calciummay leadto various cellular disorders including microtubule impairment , synaptic and mitochondrial dysfunctions , oxidative stress as well as dysregulation of Calcium
neuronal death and assess how therapies may stop the proteins ’ folding to prevent this aggregationcauseneuronal death and assess how therapies may stop the proteins ’ folding to prevent this aggregation
the loss of motor functions in PD patientscausesthe loss of motor functions in PD patients
to the formation of Lewy bodies in the brains of patients affected by Parkinson ’s disease PDleadsto the formation of Lewy bodies in the brains of patients affected by Parkinson ’s disease PD
in loss of neuron brain cells responsible for dopamine productionresultingin loss of neuron brain cells responsible for dopamine production
to altered gene expressionleadto altered gene expression
to neurotoxicityleadingto neurotoxicity
an imbalance of neurotransmitter levels in the braincausean imbalance of neurotransmitter levels in the brain
to strange faults within the hippocampal neurons ' " communication mechanismsledto strange faults within the hippocampal neurons ' " communication mechanisms
in cytotoxicityresultingin cytotoxicity
to the pathogenesis of alpha?synuclein - induced neurodegenerationcould ... leadto the pathogenesis of alpha?synuclein - induced neurodegeneration
to a chain of events , including microglial activation , inflammation , and glial and neuronal degenerationleadsto a chain of events , including microglial activation , inflammation , and glial and neuronal degeneration
PhD “ Intracellular Trafficking Dysfunction(passive) Caused byPhD “ Intracellular Trafficking Dysfunction
of the other form of the proteincomposedof the other form of the protein
2008 Cell death(passive) caused by2008 Cell death
at ProteoTechearlier discoveredat ProteoTech
to the demise of dopamine neuronscontributesto the demise of dopamine neurons
oxidative stress by engaging this mechanismcausesoxidative stress by engaging this mechanism
to the degeneration of dopaminergic neuronscontributingto the degeneration of dopaminergic neurons
additional stress to energy deprived dopamine producing cellscausingadditional stress to energy deprived dopamine producing cells