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Age - related impairment of either of these systemscausesenhanced protein aggregation
because silicone oil has been demonstratedto causeaggregation of a variety of proteins
by free radicals(passive) caused byprotein oxidative aggregation
by mutations(passive) caused byprion protein aggregation
to be involved in these diseases in part via their propensityto causetoxic aggregation of proteins
many factorscould influenceprotein aggregation propensity
the additional reactive cysteine molecule at the protein surface ... in turncausesprotein aggregation
2016 ) , Mutational probing of protein aggregatesto designaggregation - resistant proteins
by protein hydrophobic interactions(passive) caused byprotein aggregation
by N - terminal mutant huntingtin proteins(passive) caused byprotein aggregation
protein mis - folding mutationscauseprotein aggregation
by mutant huntingtin proteins(passive) caused byprotein aggregation
misfolded protein species(passive) is caused byProtein aggregation
protein thiol groupscausingprotein aggregation
Mutations that lead to the alteration in the levels of proteins with IDRscan resultin protein aggregation
Protein misfolding , protein fibril formation , and/ormay contributeprotein aggregation
Mutations in this domaincan causeprotein aggregation
The expression of the bacterial nitroreductase gene in COS-7 cellsresultsin protein aggregation
the dehydration of water molecule present between the proteinscausingaggregation of protein
Formation of disulphide bonds and hydrophobic interactionscauseprotein aggregation
oxidizing protein thiol groupscausingprotein aggregation
that presence of silicone oil as droplets in a high - concentrated protein formulationcan causeprotein aggregation
the misfolding of proteins during synthesis(passive) caused byprotein aggregation
the frequency of protein misfoldingresultsin protein aggregation
process conditionsinfluencingprotein aggregation
interact with proteinspossibly resultingin protein aggregation
mutation of the above residuescausesprotein aggregation
protein homeostasisresultingin protein aggregation
by heat or chemical stress(passive) caused byprotein aggregation
such protein instabilitydoes ... causeprotein aggregation
by expanded polyglutamine containing protein(passive) caused byprotein aggregation
Both of these mutationscauseprotein aggregation
these mutationscauseprotein aggregation
our mutationscould causeprotein aggregation
age and tau expressionmay influenceaggregation of the protein
the known factors ... andinfluencingprotein aggregation
to incorporate into ( human ) proteinscausingprotein aggregation
the cellular pathways by whichinfluenceprotein aggregation
the synthetic gene ... knownto causeaggregation of the protein
Because water is thoughtto influenceprotein aggregation
diseases(passive) caused bydiseases
in formation of insoluble inclusion bodies inside cellsmay resultin formation of insoluble inclusion bodies inside cells
in dysregulation of their activitymight resultin dysregulation of their activity
Diseases such as Parkinson and Alzheimer are thought(passive) to be caused byDiseases such as Parkinson and Alzheimer are thought
to diseaseleadingto disease
to death of dopaminergic neuronsleadsto death of dopaminergic neurons
to diseaseleadingto disease
in cell deathresultsin cell death
a fatal disease(passive) caused bya fatal disease
to the formation of AGEsleadsto the formation of AGEs
aggregation - associated diseasescauseaggregation - associated diseases
to diseasecan leadto disease
several progressive age - related brain diseases , including amyotrophic lateral sclerosis , Alzheimer 's , Parkinson 's and prion diseasecausesseveral progressive age - related brain diseases , including amyotrophic lateral sclerosis , Alzheimer 's , Parkinson 's and prion disease
several progressive age - related brain diseasescausesseveral progressive age - related brain diseases
several progressive age - related brain diseases , including amyotrophic lateral sclerosis , Alzheimer 's , Parkinson 's and prion diseasescausesseveral progressive age - related brain diseases , including amyotrophic lateral sclerosis , Alzheimer 's , Parkinson 's and prion diseases
several neurodegenerative and chronic diseases in humans and animals [ 1,2causesseveral neurodegenerative and chronic diseases in humans and animals [ 1,2
cell stress and eventually cell deathcan causecell stress and eventually cell death
to lower accumulation of insoluble scFvD1.3 proteins and reduced metabolic stressleadingto lower accumulation of insoluble scFvD1.3 proteins and reduced metabolic stress
of amyloid plaques and tau protein tanglescomposedof amyloid plaques and tau protein tangles
to disease pathogenesiscontributeto disease pathogenesis
from increased protein dissociation and subunit interactions and re - association to larger ( insoluble ) aggregates as reported for heat - processed soy proteinmight have resultedfrom increased protein dissociation and subunit interactions and re - association to larger ( insoluble ) aggregates as reported for heat - processed soy protein
to protein deposition diseaseswould leadto protein deposition diseases
to protein deposition diseaseswould leadto protein deposition diseases
to fibril formation and amyloid plaquescan leadto fibril formation and amyloid plaques
in the formation ofmay resultin the formation of
to the formation of cataractleadingto the formation of cataract
to amyloid fibril formationcan leadto amyloid fibril formation
to amyloid fibril formationleadingto amyloid fibril formation
to amyloid fibril formation andcan leadto amyloid fibril formation and
to cell dysfunctionleadingto cell dysfunction
to amyloid fibril formation and these fibrilscan leadto amyloid fibril formation and these fibrils
to increased immunogenicity and reduced efficacyleadsto increased immunogenicity and reduced efficacy
many devastating neurological and systemic diseasescausesmany devastating neurological and systemic diseases
to increased scattering of lightleadingto increased scattering of light
to common neurodegenerative diseases such as Alzheimer 's , Huntington 's , or Parkinson 's Diseasecan leadto common neurodegenerative diseases such as Alzheimer 's , Huntington 's , or Parkinson 's Disease
of proteinare composedof protein
in ion channel formationresultsin ion channel formation
the diseasedo ... causethe disease
to amyloid deposition in the brainleadingto amyloid deposition in the brain
diseases(passive) caused bydiseases