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Qaagi - Book of Why

Causes

Effects

mechanismsleadingto its activation and release of arachidonic acid

Ceramide production ... sub - toxic doses of doxorubicinresultedin an activation of the acid sphingomyelinase ( ASM ... release of ceramide and formation of ceramide - enriched membrane platforms

when activatedcausesarachidonic acid release and the subsequent activation of the neuroinflammatory pathway via COX-2

Hypoxialedacid sphingomyelinase activation and ceramide increase in hepatocytes

Rupture of lysosomescausesrelease of lysosomal enzymes into the cytosol and activation of acid hydrolases followed by autolysis

that TNF - alpha induces sphingomyelinase hydrolysisresultingin PLA2G2A activation and arachidonic acid release

intense physical exercisecausesarachidonic acid to be released and metabolized to active prostaglandins

alternative regulatory pathwayscan leadto cPLA2 activation and arachidonic acid release

Decreased expression of Lon proteaseledto the activation of the Rcs phosphorelay system and the overproduction of colanic acid

to massive production of oxygen free radicals and oxidative injuryleadingto massive production of oxygen free radicals and oxidative injury

as a result of PKC activation elicited by both presynaptic neurotransmitter release and activation of NMDA receptors in the spinal neuronsmay ... be provokedas a result of PKC activation elicited by both presynaptic neurotransmitter release and activation of NMDA receptors in the spinal neurons

the formation of the mitogenetic metabolite 1,3-hydroxyoctadecadienoic acidthereby preventingthe formation of the mitogenetic metabolite 1,3-hydroxyoctadecadienoic acid

to DR - induced necrosis ( 174to contributeto DR - induced necrosis ( 174

to renal injury and urothelial cancerleadingto renal injury and urothelial cancer

the AP-1-dependent pathway.29negatively influencesthe AP-1-dependent pathway.29

to PR degenerationleadsto PR degeneration

to the formation of multiple eicosanoids that are involved in inflammationcan leadto the formation of multiple eicosanoids that are involved in inflammation

a destabilization of the membrane structure assumingwould causea destabilization of the membrane structure assuming

Inhibitory transmitterspreventInhibitory transmitters

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Smart Reasoning:

C&E

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