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Qaagi - Book of Why

Causes

Effects

8,9 ) Hemolysis in HS ... an intrinsic membrane protein defectleadsto abnormal RBC morphology

Electrolyte and Metabolic Abnormalities Echinocytes and echinocytic elliptocytes(passive) Caused byAbnormal RBC Morphology

deficiency of lipids and vitamin Ecausingabnormal morphology of RBCs

Iron Deficiency Iron deficiency , whatever the underlying cause(passive) Caused byAbnormal RBC Morphology

Mechanical Fragmentation(passive) Caused byAbnormal RBC Morphology

the ability of trauma hemorrhagic shock ( T / HS ) lymphto causeabnormal RBC deformability

22 women in child bearing yearscausesabnormal rbc morphology

Hepatic Disease Abnormal(passive) Caused byAbnormal RBC Morphology

Immune - Mediated Disease(passive) Caused byAbnormal RBC Morphology

Haemolysis in HS ... an intrinsic membrane protein defectleadsto abnormal RBC morphology

Oxidative Damage Oxidative damage to hemoglobin results in Heinz body formation(passive) Caused byAbnormal RBC Morphology

a reticulocyte count , iron studies , tests for vitamin B12 and folate , G6PD , or hemoglobinopathy evaluation to help make a diagnosismay prompta reticulocyte count , iron studies , tests for vitamin B12 and folate , G6PD , or hemoglobinopathy evaluation to help make a diagnosis

that have abnormally high membrane cholesterol contentmay resultthat have abnormally high membrane cholesterol content

from various diseases , sickle cell anemia and many other anemia disorderscan also resultfrom various diseases , sickle cell anemia and many other anemia disorders

from defects in the CDC55 gene , which encodes the yeast homolog of a different B subunit of another form of 2A phosphatase , PP2A1resultingfrom defects in the CDC55 gene , which encodes the yeast homolog of a different B subunit of another form of 2A phosphatase , PP2A1

to sicklingcan leadto sickling

to endothelial injury , mitochondrial dysfunction , vasodilation , and fluid redistributionleadsto endothelial injury , mitochondrial dysfunction , vasodilation , and fluid redistribution

from malarial infection detected as a flag Propagation cycle Schizontsresultingfrom malarial infection detected as a flag Propagation cycle Schizonts

from defective megakaryopoiesisresultingfrom defective megakaryopoiesis

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