9 Mutation Types of mutationsmay causeframeshift or null mutation
this human caseresultingfrom a homozygous null mutation ( 9
the lacZ gene was placed in frame downstream of the initiation ATG of the ZO-2 or ZO-3 generesultingin a null mutation of the corresponding gene
The deficiency of c - GMP PDE in photoreceptors of the rd mouseresultingfrom a null mutation in the PDE6B gene
the genetargeting resultedin a functional null mutation
carrying the GRN deletion g.101349_101355delCTGCTGT ,resultingin the C157KfsX97 null mutation
the gene disruptionresultedin a null mutation of RAGE
2011;88(3):382 - 390causesCcdc66 null mutation
Targeted integration of these constructs deletes the AID coding region from the third codon to the endresultingin an AID null mutation
The discrepancy between the effective regeneration in the mdx mouse and its progressive failure in DMDhas promptedthe breeding of a telomerase - null mutation
the Rockefeller University , NY , NY , USAdiscoverednull mutations in ISG15
by chromosome breaks(passive) caused bynull mutations
Intragenic mutations most commonly include insertion of a premature termination codonleadingto null mutations
The DNA insertion ... is expectedto resultin a null mutation
The T - DNA insertion ... was expectedto resultin a null mutation
an 80 % chancewill causea bad mutation
the T - DNA insertioncausesa null mutation
gene truncations either by a lack of expression or expression of a severely shortened / compromised gene product(passive) are caused byNull mutations
Subsequently , his postdoctoral training took place at the Rockefeller University , NY , NY , USAdiscoverednull mutations in ISG15
a polymorphism in the DEFB126 gene , a dinucleotide deletion in the coding region of the DEFB126 mRNAresultsin a null mutation
a splice site sequencecausesa null mutation
Major mutationcausingNull mutation
the deletions in these genesresultin a null mutation
to insert a resistance cassette in place of our targeted generesultingin a null mutation
Such insertionwould resultin a null mutation
This insertionprobably resultsin a null mutation
while others ( 10 , 11 , and 23 bp ) cause frameshiftsresultingin null mutations
Found in Severe Infant Epilepsy Researchershave discovereda ? missing mutation
shownresultsin a null mutation
Children?s Hospital of Philadelphia Researchershave discovereda ? missing mutation
is expectedto resultin a null mutation
this disruptionresultsin a null mutation
ATG codon ... likelyto resultin a null mutation
any lesioncausingan X-->T mutation
the mRNAleadingto a NULL mutation
the sensecausesa null mutation
by the frameshift in the * E. coli(passive) caused bya null mutation
phosphorylationleadingto a null mutation
phosphorylation ... andleadingto a null mutation
a premature termination codon ( PTC(passive) caused bya nonsense mutation
in premature termination codon correspondingresultingin premature termination codon corresponding
to degeneration of the photoreceptor layer ( Lem et al . , 1999leadsto degeneration of the photoreceptor layer ( Lem et al . , 1999
Slender rice , a constitutive gibberellin response mutant(passive) is caused bySlender rice , a constitutive gibberellin response mutant
Y Slender rice , a constitutive gibberellin response mutant(passive) is caused byY Slender rice , a constitutive gibberellin response mutant
to the diminished expression of Brn3aleadsto the diminished expression of Brn3a
the growth and transcriptional defects(passive) caused bythe growth and transcriptional defects
a similar age - dependent neuropathology that includes many features of prion diseases but without accumulation of protease - resistant prion proteincausesa similar age - dependent neuropathology that includes many features of prion diseases but without accumulation of protease - resistant prion protein
to a reduction in light - induced stomatal opening and to an enhanced drought toleranceleadsto a reduction in light - induced stomatal opening and to an enhanced drought tolerance
in premature protein terminationresultingin premature protein termination
to embryonic death [ 3would leadto embryonic death [ 3
to embryonic deathwould leadto embryonic death
cell or embryo lethalitycan causecell or embryo lethality
the defects(passive) caused bythe defects
a gene(passive) caused bya gene
in a premature stop codonresultsin a premature stop codon
to embryonic death.[8would leadto embryonic death.[8
to perinatal lethalityleadsto perinatal lethality
to deathleadsto death
a failure in temporal developmentcausesa failure in temporal development
a defect in sporulationcausinga defect in sporulation
in a significant decrease in total protease activityresultedin a significant decrease in total protease activity
female sterilitycausesfemale sterility
defects in female meiotic spindle assemblycausesdefects in female meiotic spindle assembly
to the lack of a vasculature and results in very few endothelial cellsleadsto the lack of a vasculature and results in very few endothelial cells
in haploinsufficiencyresultingin haploinsufficiency
to haploinsufficiencyleadingto haploinsufficiency
an age - related progressive neurodegenerative phenotype characterised by spongiform degeneration , neuronal loss and astrocytosiscausesan age - related progressive neurodegenerative phenotype characterised by spongiform degeneration , neuronal loss and astrocytosis
a significant decrease in longevitycauseda significant decrease in longevity
to an enlarged olfactory bulb and supernumeraryleadsto an enlarged olfactory bulb and supernumerary
to an enlarged olfactory bulb and supernumerary , ectopic olfactory glomerulileadsto an enlarged olfactory bulb and supernumerary , ectopic olfactory glomeruli
in a Ced phenotype that is slightly weaker than that of rab-35(b1013 ) mutants ( Figs 3A and S2Bresultedin a Ced phenotype that is slightly weaker than that of rab-35(b1013 ) mutants ( Figs 3A and S2B