Loading ...
the gene disruptioncreateda null mutation
Disruption of Arabidopsis Hsa32 by T - DNA insertionledto a null mutation
the targeting eventresultedin a null mutation
Interestingly , insertion of the PGK - Neo cassette ( usedto createthe null mutation
this plasmid insertioncreateda null mutation of vanN.
the targeted disruption of the mouseETB gene(passive) created bya null mutation
the homozygous gene trap insertionresultedin a null mutation
a MECP2 mutation in a classic female RTT patient involving rearrangements that remove exons 3 and 4creatinga functionally null mutation
Homologous recombination deleted this region of the generesultingin a null mutation
a lacZ insertion in Hdac2 , which is purportedto createa null mutation
The disruption of the AtPHS1 gene in Atphs1 - 1 is expectedto resultin a null mutation
The insertion of a trap vector into the second intron of this generesultedin the null mutation
A germline insertion of a retrovirus into the 5 ’ end of a genecould causea null mutation
using ends - out homologous recombination - mediated gene targeting ( Gong and Golic , 2003(passive) was createdA null mutation in lft
The T - DNA ... most likelyresultedin a null mutation
codon ... likelyto resultin a null mutation
a T base pair insertion in exon 11creatinga null mutation
gene targeting in the R1 ES cell line(passive) created byNull mutation
a gene deletionresultsin a null mutation
the insertion of the neomycin resistance cassette in the second exon of the Ncx3 genecreateda null mutation
targeting just a single geneto createa null mutation
that the G4SP MO is unclearcreatean equivalent of a null mutation
Homologous recombination with this targeting vector results in a loss of exon 2 and in inadequate splicingresultingin a null mutation
the modification of the H - ras generesultedin a null mutation
Homologous recombination of the targeting ... the mouse Bai1 locus results in deletion of exon 2 ( E2leadsto a null mutation
the insertion of a gene trap vector between exons 3 and 4 of the Sh3pxd2b gene , which appears to result in a complete loss of gene expression [ 7(passive) created byan engineered null mutation
the insertion of an F element in a coding exon which disrupts the dPTEN ORF after amino acid 89 ( 30(passive) caused bya putative null mutation
the deletion of exon 6 in the perlecan geneleadsto a constitutive null mutation
to insert a resistance cassette in place of our targeted generesultingin a null mutation
the frameshift in the E. coli DH5α ygaG gene(passive) caused bya null mutation
Patients with defective talin-1 ( gene namewould resultnull mutation
From the phglo2 alleles ( Table 1 ) , we have selected phglo2 - 3 because in this line , the first exon encoding the DNA binding MADS domain is disrupted by the transposon insertionmost likely resultingin a null mutation
a deficiency in the hig gene ( Hoshino et al . , 1993(passive) caused bya null mutation
a polymorphism in the DEFB126 gene , a dinucleotide deletion in the coding region of the DEFB126 mRNAresultsin a null mutation
that the duplicated region is located inside the CFTR gene and interferes with the transcription or translation processthus resultingin a null mutation
This nonconditional potential allele has a trapping cassette SA - βgeo - pA ( splice acceptor – β - geo – polyA ) flanked by flippase recombinase target FRT sites upstream of exon 4 , resulting in truncation of the endogenous transcript and , thuscreatinga constitutive null mutation
The gene - trap vector was here integrated in an inverted orientation into the 5′ end of exon 8 of the nephrin generesultingin a null mutation
It is then possible for a recombination event to take place where you swap the DNA from a wild type fly with the DNA that lacks your gene of interestthereby creatinga null mutation
In the phyA-4 mutant , Tos17 is inserted in the middle of the second exon of the PHYA gene ( 1724th nucleotide in the sequence of PHYA cDNA , accession number AB109891resultinga null mutation
by inserting a HincII fragment from pUCKan , containing the kanamycin resistance gene , into p11/2/13 at a unique StyI site , which maps to the codon for amino acid residue 124 of PilU.(passive) was createdA pilU null mutation
sustained partial correction of canine hemophilia B(passive) caused bysustained partial correction of canine hemophilia B
deafness in homozygotes ( dfw(2J)/dfw(2Jcausingdeafness in homozygotes ( dfw(2J)/dfw(2J
auxotrophy for adenine and histidine 905934causesauxotrophy for adenine and histidine 905934
a gradual loss of viability during starvation ( 3 , 4 , 5 and see Summary Paragraphcausesa gradual loss of viability during starvation ( 3 , 4 , 5 and see Summary Paragraph
embryonic lethality in Arabidopsis thalianacausesembryonic lethality in Arabidopsis thaliana
petite " phenotype - slow growth on glucose and no growth with non - fermentable carbon sources ... indicating respiratory deficiency ; null mutant also shows increased frequency of mitochondrial genome loss ( rho- mutations ) 167 total interactions for 121 unique genes Negative Genetic : 127causespetite " phenotype - slow growth on glucose and no growth with non - fermentable carbon sources ... indicating respiratory deficiency ; null mutant also shows increased frequency of mitochondrial genome loss ( rho- mutations ) 167 total interactions for 121 unique genes Negative Genetic : 127
petite " phenotype - slow growth on glucose and no growth with non - fermentable carbon sources ... indicating respiratory deficiency ; null mutant also shows increased frequency of mitochondrial genome loss ( rho- mutations ) and increased number of peroxisomes 63 total interactions for 55 unique genescausespetite " phenotype - slow growth on glucose and no growth with non - fermentable carbon sources ... indicating respiratory deficiency ; null mutant also shows increased frequency of mitochondrial genome loss ( rho- mutations ) and increased number of peroxisomes 63 total interactions for 55 unique genes
to a partial deletion of the seventh transmembrane domain of the GnRHRleadingto a partial deletion of the seventh transmembrane domain of the GnRHR
auxotrophy for adenine and histidine ( 946 aacausesauxotrophy for adenine and histidine ( 946 aa
auxotrophy for adenine and histidine ADE1 GUA1causesauxotrophy for adenine and histidine ADE1 GUA1
the expression of SBEIIa , ae1 , an uncharacterized mutation in the gene coding for SBEIIb , or ae−Bpreventingthe expression of SBEIIa , ae1 , an uncharacterized mutation in the gene coding for SBEIIb , or ae−B
in early embryonic deathresultedin early embryonic death
rapid mislocalization of the late - Golgi membrane proteins A - ALP and Kex2p to the vacuole [ 31causesrapid mislocalization of the late - Golgi membrane proteins A - ALP and Kex2p to the vacuole [ 31
auxotrophy for adenine and histidine ( 1 , 2 , 3causesauxotrophy for adenine and histidine ( 1 , 2 , 3
complete MTP deficiency [ 3 ] , with fetuses that accumulate long chain fatty acid metabolites identical to the human deficiencycausingcomplete MTP deficiency [ 3 ] , with fetuses that accumulate long chain fatty acid metabolites identical to the human deficiency
to early embryonic lethality , as it does in Tln1−/− mice.15would leadto early embryonic lethality , as it does in Tln1−/− mice.15
to mid - gestation lethality [ 1 - 4leadsto mid - gestation lethality [ 1 - 4
to severe growth defects , aberrant multibudded morphology , and mating defectsleadsto severe growth defects , aberrant multibudded morphology , and mating defects
DTC defects(passive) caused byDTC defects
a similar age - dependent neuropathology that includes many features of prion ( 显示 PRNP ELISA试剂盒causesa similar age - dependent neuropathology that includes many features of prion ( 显示 PRNP ELISA试剂盒
56 6 Frontotemporal dementia in a large Swedish family(passive) is caused by56 6 Frontotemporal dementia in a large Swedish family
embryonic lethality around day 10.5 of the embryonic developmentcausedembryonic lethality around day 10.5 of the embryonic development
in corneal epithelial hyperproliferation , inflammation , and neovascularization in the A.BY backgroundresultsin corneal epithelial hyperproliferation , inflammation , and neovascularization in the A.BY background
significant alterations in transposable element expression in both the naive and primed states of human pluripotency ... and phenotypically this has limited effects on self - renewal , instead causing a loss of germline competencycausessignificant alterations in transposable element expression in both the naive and primed states of human pluripotency ... and phenotypically this has limited effects on self - renewal , instead causing a loss of germline competency
Calne DB 1416801 1992 Frontotemporal dementia in a large Swedish family(passive) is caused byCalne DB 1416801 1992 Frontotemporal dementia in a large Swedish family
cell migration defectscausescell migration defects
the growth and transcriptional defects(passive) caused bythe growth and transcriptional defects
ciliary sensing defects(passive) created byciliary sensing defects
to an enlarged olfactory bulb and supernumerary , ectopic olfactory glomeruli Ernesto Salcedo , Nicole M. Cruz , Xuan Ly , Beth A. Welander , Kyle Hanson , Eugene Kronberg , Diego Restrepoleadsto an enlarged olfactory bulb and supernumerary , ectopic olfactory glomeruli Ernesto Salcedo , Nicole M. Cruz , Xuan Ly , Beth A. Welander , Kyle Hanson , Eugene Kronberg , Diego Restrepo
defects in axon positioning in the VNCcausesdefects in axon positioning in the VNC
balance and hearing defects in micecausedbalance and hearing defects in mice
abnormal spindle morphology and defects in cytokinesiscausesabnormal spindle morphology and defects in cytokinesis
to heart defects , including cardiac edema and hypoplasia of the SANmay leadto heart defects , including cardiac edema and hypoplasia of the SAN
late flowering by increasing OsLFL1 expression and decreasing Ehd1 expression Ehd1 , OsVIL2 , OsVIL2 functions with PRC2 to induce flowering by repressing OsLFL1 in rice ... In osvil2 mutants OsLFL1 expression was increased , but that of Ehd1 , Hd3a and RFT1 was reduced Ehd1 , OsVIL2 , OsVIL2 functions with PRC2 to induce flowering by repressing OsLFL1 in rice , As observed from osvil2 ... a null mutation of OsEMF2b caused late flowering by increasing OsLFL1 expression and decreasing Ehd1 expression CKIcausedlate flowering by increasing OsLFL1 expression and decreasing Ehd1 expression Ehd1 , OsVIL2 , OsVIL2 functions with PRC2 to induce flowering by repressing OsLFL1 in rice ... In osvil2 mutants OsLFL1 expression was increased , but that of Ehd1 , Hd3a and RFT1 was reduced Ehd1 , OsVIL2 , OsVIL2 functions with PRC2 to induce flowering by repressing OsLFL1 in rice , As observed from osvil2 ... a null mutation of OsEMF2b caused late flowering by increasing OsLFL1 expression and decreasing Ehd1 expression CKI
2.View ArticlePubMedPubMed CentralGoogle ScholarSkoglund L , Brundin R , Olofsson T , Kalimo H , Ingvast S , Blom ES , Giedraitis V , Ingelsson M , Lannfelt L , Basun H , Glaser A : Frontotemporal dementia in a large Swedish family(passive) is caused by2.View ArticlePubMedPubMed CentralGoogle ScholarSkoglund L , Brundin R , Olofsson T , Kalimo H , Ingvast S , Blom ES , Giedraitis V , Ingelsson M , Lannfelt L , Basun H , Glaser A : Frontotemporal dementia in a large Swedish family
defects in female meiotic spindle assembly ( Mains et al . , 1990causesdefects in female meiotic spindle assembly ( Mains et al . , 1990
rapid repair of DSBs using a sister chromatid , thus bypassing formation of checkpoint - activating lesionscausesrapid repair of DSBs using a sister chromatid , thus bypassing formation of checkpoint - activating lesions
defects indicative of weakened cell walls , such as reduced resistance to low pH , SDS , Calcofluor White and caffeinecausesdefects indicative of weakened cell walls , such as reduced resistance to low pH , SDS , Calcofluor White and caffeine
morphological and polarity phenotypes , including pear shaped and spherical cells , thus the name Pal1 for pears and lemonscausesmorphological and polarity phenotypes , including pear shaped and spherical cells , thus the name Pal1 for pears and lemons
a dramatic decrease in ecdysone levels ... indicating that E75A plays a dual role , acting both downstream of ecdysone as an 20E target during the onset of metamorphosis and also upstream of ecdysone as a regulator of ecdysone production in the prothoracic gland Bialecki et alcausesa dramatic decrease in ecdysone levels ... indicating that E75A plays a dual role , acting both downstream of ecdysone as an 20E target during the onset of metamorphosis and also upstream of ecdysone as a regulator of ecdysone production in the prothoracic gland Bialecki et al