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Smart Reasoning:

C&E

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Qaagi - Book of Why

Causes

Effects

9 Mutation Types of mutationsmay causeframeshift or null mutation

this human caseresultingfrom a homozygous null mutation ( 9

the lacZ gene was placed in frame downstream of the initiation ATG of the ZO-2 or ZO-3 generesultingin a null mutation of the corresponding gene

The deficiency of c - GMP PDE in photoreceptors of the rd mouseresultingfrom a null mutation in the PDE6B gene

the genetargeting resultedin a functional null mutation

carrying the GRN deletion g.101349_101355delCTGCTGT ,resultingin the C157KfsX97 null mutation

the gene disruptionresultedin a null mutation of RAGE

2011;88(3):382 - 390causesCcdc66 null mutation

Targeted integration of these constructs deletes the AID coding region from the third codon to the endresultingin an AID null mutation

The discrepancy between the effective regeneration in the mdx mouse and its progressive failure in DMDhas promptedthe breeding of a telomerase - null mutation

the Rockefeller University , NY , NY , USAdiscoverednull mutations in ISG15

by chromosome breaks(passive) caused bynull mutations

Intragenic mutations most commonly include insertion of a premature termination codonleadingto null mutations

The DNA insertion ... is expectedto resultin a null mutation

The T - DNA insertion ... was expectedto resultin a null mutation

an 80 % chancewill causea bad mutation

the T - DNA insertioncausesa null mutation

gene truncations either by a lack of expression or expression of a severely shortened / compromised gene product(passive) are caused byNull mutations

Subsequently , his postdoctoral training took place at the Rockefeller University , NY , NY , USAdiscoverednull mutations in ISG15

a polymorphism in the DEFB126 gene , a dinucleotide deletion in the coding region of the DEFB126 mRNAresultsin a null mutation

a splice site sequencecausesa null mutation

Major mutationcausingNull mutation

the deletions in these genesresultin a null mutation

to insert a resistance cassette in place of our targeted generesultingin a null mutation

Such insertionwould resultin a null mutation

This insertionprobably resultsin a null mutation

while others ( 10 , 11 , and 23 bp ) cause frameshiftsresultingin null mutations

Found in Severe Infant Epilepsy Researchershave discovereda ? missing mutation

shownresultsin a null mutation

Children?s Hospital of Philadelphia Researchershave discovereda ? missing mutation

is expectedto resultin a null mutation

this disruptionresultsin a null mutation

ATG codon ... likelyto resultin a null mutation

any lesioncausingan X-->T mutation

the mRNAleadingto a NULL mutation

the sensecausesa null mutation

by the frameshift in the * E. coli(passive) caused bya null mutation

phosphorylationleadingto a null mutation

phosphorylation ... andleadingto a null mutation

a premature termination codon ( PTC(passive) caused bya nonsense mutation

in premature termination codon correspondingresultingin premature termination codon corresponding

to degeneration of the photoreceptor layer ( Lem et al . , 1999leadsto degeneration of the photoreceptor layer ( Lem et al . , 1999

Slender rice , a constitutive gibberellin response mutant(passive) is caused bySlender rice , a constitutive gibberellin response mutant

Y Slender rice , a constitutive gibberellin response mutant(passive) is caused byY Slender rice , a constitutive gibberellin response mutant

lethalitycauseslethality

to perinatal lethalityleadsto perinatal lethality

genecausesgene

reduced gustatory innervation(passive) caused byreduced gustatory innervation

to the diminished expression of Brn3aleadsto the diminished expression of Brn3a

the growth and transcriptional defects(passive) caused bythe growth and transcriptional defects

a similar age - dependent neuropathology that includes many features of prion diseases but without accumulation of protease - resistant prion proteincausesa similar age - dependent neuropathology that includes many features of prion diseases but without accumulation of protease - resistant prion protein

to a reduction in light - induced stomatal opening and to an enhanced drought toleranceleadsto a reduction in light - induced stomatal opening and to an enhanced drought tolerance

in premature protein terminationresultingin premature protein termination

to embryonic death [ 3would leadto embryonic death [ 3

to embryonic deathwould leadto embryonic death

cell or embryo lethalitycan causecell or embryo lethality

the defects(passive) caused bythe defects

a gene(passive) caused bya gene

in a premature stop codonresultsin a premature stop codon

to embryonic death.[8would leadto embryonic death.[8

to perinatal lethalityleadsto perinatal lethality

to deathleadsto death

a failure in temporal developmentcausesa failure in temporal development

a defect in sporulationcausinga defect in sporulation

in a significant decrease in total protease activityresultedin a significant decrease in total protease activity

female sterilitycausesfemale sterility

defects in female meiotic spindle assemblycausesdefects in female meiotic spindle assembly

to the lack of a vasculature and results in very few endothelial cellsleadsto the lack of a vasculature and results in very few endothelial cells

in haploinsufficiencyresultingin haploinsufficiency

to haploinsufficiencyleadingto haploinsufficiency

an age - related progressive neurodegenerative phenotype characterised by spongiform degeneration , neuronal loss and astrocytosiscausesan age - related progressive neurodegenerative phenotype characterised by spongiform degeneration , neuronal loss and astrocytosis

Alpha-1 antitrypsin deficiency ... ] | Read by(passive) caused byAlpha-1 antitrypsin deficiency ... ] | Read by

auxotrophycausesauxotrophy

cmoB2resultscmoB2

auxotrophy ... Biologicalcausesauxotrophy ... Biological

a significant decrease in longevitycauseda significant decrease in longevity

to an enlarged olfactory bulb and supernumeraryleadsto an enlarged olfactory bulb and supernumerary

to an enlarged olfactory bulb and supernumerary , ectopic olfactory glomerulileadsto an enlarged olfactory bulb and supernumerary , ectopic olfactory glomeruli

in a Ced phenotype that is slightly weaker than that of rab-35(b1013 ) mutants ( Figs 3A and S2Bresultedin a Ced phenotype that is slightly weaker than that of rab-35(b1013 ) mutants ( Figs 3A and S2B

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Smart Reasoning:

C&E

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